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9 Approved in 2005, exenatide was the first GLP-1 drug to be made available, and later modifications allowed for its extended release

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Buse, J.C

Novo Nordisk first studied it in the late 1990s

Luo X, Hu Y, He S, Ye Q, Lv Z, Liu J, Chen X

In a phase 2 clinical trial for obesity, people taking 12 mg of retatrutide lost an average of 17.5% of their body weight in 24 weeks and 24.2% in 48 weeks (about eleven months)